The first museum hotel Nestled in downtown Louisville on historic West Main Street, along Museum Row, 21c Museum Hotel is a multi-venue contemporary art museum, an award-winning 91-room boutique hotel, and home to acclaimed Proof on Main restaurant, led by executive chef Jonathan Searle. Voted #1 Hotel in the South and #6 in the USA by Conde Nast Traveler 2019 Readers’ Choice Awards. Stay with us and the iconic Red Penguin. The world has changed over the last several months and here at 21c, we have made some changes too. One thing remains constant. Our top priority is the safety and wellness of our teammates and guests. Our website has everything you need to know to return to travel with 21c. We can't wait to welcome you back to Proof on Main and 21c Louisville!